Posted on Tuesday 4th August 2015
The diabetes team at Guy's and St Thomas' Hospitals and King's College London are carrying out pioneering research work aimed at developing new treatments to preserve insulin production in people with recently diagnosed type 1 diabetes. The ultimate aim is to develop a cure for type 1 diabetes.
Type 1 diabetes is caused by the body's own immune system attacking and destroying the insulin producing (beta) cells in the pancreas. This process is often ongoing for many months, and sometimes years, after diagnosis. The aim of this pioneering research work is to produce a new treatment which is designed to switch off the white blood cells which damage the beta cells thereby preserving insulin production by the pancreas gland and reducing, or even preventing, the need for insulin injections.
The new treatment consists of fragments of peptides (proteins) that are normally contained within the beta cells. It is administered by means of multiple small injections into the skin a bit like a vaccination.
Our scientists have undertaken a huge amount of work developing these potential new peptide treatments. We have now completed several early studies using these peptide vaccines in people with type 1 diabetes with very encouraging results.
We have now started the next phase of this work which involves the administration of a more sophisticated form of this peptide vaccine. We are looking for people willing to help with this study. To participate you must be 18 - 45 years old and have developed type 1 diabetes less than 4 years ago. If you would like to participate or just want more information go to our MultipeT1De website.